[HTML][HTML] Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity
M Mueller, A Thorell, T Claudel, P Jha, H Koefeler… - Journal of …, 2015 - Elsevier
Background & Aims Bile acids (BAs) are major regulators of hepatic BA and lipid metabolism
but their mechanisms of action in non-alcoholic fatty liver disease (NAFLD) are still poorly
understood. Here we aimed to explore the molecular and biochemical mechanisms of
ursodeoxycholic acid (UDCA) in modulating the cross-talk between liver and visceral white
adipose tissue (vWAT) regarding BA and cholesterol metabolism and fatty acid/lipid
partitioning in morbidly obese NAFLD patients. Methods In this randomized controlled …
but their mechanisms of action in non-alcoholic fatty liver disease (NAFLD) are still poorly
understood. Here we aimed to explore the molecular and biochemical mechanisms of
ursodeoxycholic acid (UDCA) in modulating the cross-talk between liver and visceral white
adipose tissue (vWAT) regarding BA and cholesterol metabolism and fatty acid/lipid
partitioning in morbidly obese NAFLD patients. Methods In this randomized controlled …
