[HTML][HTML] The farnesoid X receptor controls gene expression in a ligand-and promoter-selective fashion
JL Lew, A Zhao, J Yu, L Huang, N De Pedro… - Journal of Biological …, 2004 - ASBMB
Farnesoid X receptor (FXR) is a nuclear receptor for bile acids. Ligand activated-FXR
regulates transcription of genes to allow feedback control of bile acid synthesis and
secretion. There are five major bile acids in humans. We have previously demonstrated that
lithocholate acts as an FXR antagonist, and here we show that the other four bile acids,
chenodeoxycholate (CDCA), deoxycholate (DCA), cholate (CA), and ursodeoxycholate
(UDCA), act as selective FXR agonists in a gene-specific fashion. In an in vitro coactivator …
regulates transcription of genes to allow feedback control of bile acid synthesis and
secretion. There are five major bile acids in humans. We have previously demonstrated that
lithocholate acts as an FXR antagonist, and here we show that the other four bile acids,
chenodeoxycholate (CDCA), deoxycholate (DCA), cholate (CA), and ursodeoxycholate
(UDCA), act as selective FXR agonists in a gene-specific fashion. In an in vitro coactivator …