Trypanosome lytic factor, a subclass of high-density lipoprotein, forms cation-selective pores in membranes
M del Pilar Molina-Portela, EB Lugli… - Molecular and …, 2005 - Elsevier
Trypanosome lytic factor 1 (TLF1) is a subclass of human high-density lipoprotein that kills
some African trypanosomes thereby protecting humans from infection. We have shown that
TLF1 is a 500kDa HDL complex composed of lipids and at least seven different proteins.
Here we present evidence outlining a new paradigm for the mechanism of lysis; TLF1 forms
cation-selective pores in membranes. We show that the replacement of external Na+ (23Da)
with the larger tetramethylammonium+, choline+ and tetraethylammonium+ ions (74Da …
some African trypanosomes thereby protecting humans from infection. We have shown that
TLF1 is a 500kDa HDL complex composed of lipids and at least seven different proteins.
Here we present evidence outlining a new paradigm for the mechanism of lysis; TLF1 forms
cation-selective pores in membranes. We show that the replacement of external Na+ (23Da)
with the larger tetramethylammonium+, choline+ and tetraethylammonium+ ions (74Da …