Acetate, the shortest chain fatty acid, has been implicated in providing health benefits
whether it is derived from the diet or is generated from microbial fermentation of fiber in the
gut. These health benefits range widely from improved cardiac function to enhanced red
blood cell generation and memory formation. Understanding how acetate could influence so
many disparate biological functions is now an area of intensive research. Protein acetylation
is one of the most common post-translational modifications and increased systemic acetate …

Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether
derived from the diet or from fermentation in the colon, has been implicated in a range of
health benefits. Acetate is also generated in and released from various tissues including the
intestine and liver, and is generated within all cells by deacetylation reactions. To be utilized,
all acetate, regardless of the source, must be converted to acetyl coenzyme A (acetyl-CoA),
which is carried out by enzymes known as acyl-CoA short-chain synthetases. Acyl-CoA short …