[HTML][HTML] Protein phosphatase 2A activation as a therapeutic strategy for managing MYC-driven cancers
CC Farrington, E Yuan, S Mazhar, S Izadmehr… - Journal of Biological …, 2020 - ASBMB
The tumor suppressor protein phosphatase 2A (PP2A) is a serine/threonine phosphatase
whose activity is inhibited in most human cancers. One of the best-characterized PP2A
substrates is MYC proto-oncogene basic helix–loop–helix transcription factor (MYC), whose
overexpression is commonly associated with aggressive forms of this disease. PP2A directly
dephosphorylates MYC, resulting in its degradation. To explore the therapeutic potential of
direct PP2A activation in a diverse set of MYC-driven cancers, here we used biochemical …
whose activity is inhibited in most human cancers. One of the best-characterized PP2A
substrates is MYC proto-oncogene basic helix–loop–helix transcription factor (MYC), whose
overexpression is commonly associated with aggressive forms of this disease. PP2A directly
dephosphorylates MYC, resulting in its degradation. To explore the therapeutic potential of
direct PP2A activation in a diverse set of MYC-driven cancers, here we used biochemical …
