Role of ragulator in the regulation of mechanistic target of rapamycin signaling in podocytes and glomerular function
Y Yao, J Wang, S Yoshida, S Nada… - Journal of the …, 2016 - journals.lww.com
Aberrant activation of mechanistic target of rapamycin complex 1 (mTORC1) in glomerular
podocytes leads to glomerular insufficiency and may contribute to the development of
glomerular diseases, including diabetic nephropathy. Thus, an approach for preventing
mTORC1 activation may allow circumvention of the onset and progression of mTORC1-
dependent podocyte injury and glomerular diseases. mTORC1 activation requires inputs
from both growth factors and nutrients that inactivate the tuberous sclerosis complex (TSC) …
podocytes leads to glomerular insufficiency and may contribute to the development of
glomerular diseases, including diabetic nephropathy. Thus, an approach for preventing
mTORC1 activation may allow circumvention of the onset and progression of mTORC1-
dependent podocyte injury and glomerular diseases. mTORC1 activation requires inputs
from both growth factors and nutrients that inactivate the tuberous sclerosis complex (TSC) …