Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice
YK Oh, AR Bachar, DG Zacharias, SG Kim, J Wan… - Atherosclerosis, 2011 - Elsevier
OBJECTIVE: Humanin (HN) is a cytoprotective peptide derived from endogenous
mitochondria, expressed in the endothelial layer of human vessels, but its role in
atherogenesis in vivo is not known. In vitro study, however, HN reduced oxidized low-density
lipoprotein induced formation of reactive oxygen species and apoptosis. The present study
tested the hypothesis that long term treatment with HN will have a protective role against
endothelial dysfunction and progression of atherosclerosis in vivo. METHODS AND …
mitochondria, expressed in the endothelial layer of human vessels, but its role in
atherogenesis in vivo is not known. In vitro study, however, HN reduced oxidized low-density
lipoprotein induced formation of reactive oxygen species and apoptosis. The present study
tested the hypothesis that long term treatment with HN will have a protective role against
endothelial dysfunction and progression of atherosclerosis in vivo. METHODS AND …
