The role of complement in transfusion-related acute lung injury
I Jongerius, L Porcelijn, AE van Beek… - Transfusion medicine …, 2019 - Elsevier
Transfusion-related acute lung injury (TRALI) is a life-threatening complication of acute
respiratory distress occurring within 6 hours of blood transfusion. TRALI is one of the leading
causes of transfusion-related fatalities and specific therapies are unavailable. Neutrophils
are recognized as the major pathogenic cells, whereas T regulatory cells and dendritic cells
appear to be important for protection against TRALI. The pathogenesis, however, is complex
and incompletely understood. It is frequently postulated that the complement system plays …
respiratory distress occurring within 6 hours of blood transfusion. TRALI is one of the leading
causes of transfusion-related fatalities and specific therapies are unavailable. Neutrophils
are recognized as the major pathogenic cells, whereas T regulatory cells and dendritic cells
appear to be important for protection against TRALI. The pathogenesis, however, is complex
and incompletely understood. It is frequently postulated that the complement system plays …
