Effect of Bronchoalveolar Lavage–directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with Cystic Fibrosis: A randomized trial
CE Wainwright, S Vidmar, DS Armstrong, CA Byrnes… - Jama, 2011 - jamanetwork.com
Context Early pulmonary infection in children with cystic fibrosis leads to increased morbidity
and mortality. Despite wide use of oropharyngeal cultures to identify pulmonary infection,
concerns remain over their diagnostic accuracy. While bronchoalveolar lavage (BAL) is an
alternative diagnostic tool, evidence for its clinical benefit is lacking. Objective To determine
if BAL-directed therapy for pulmonary exacerbations during the first 5 years of life provides
better outcomes than current standard practice relying on clinical features and …
and mortality. Despite wide use of oropharyngeal cultures to identify pulmonary infection,
concerns remain over their diagnostic accuracy. While bronchoalveolar lavage (BAL) is an
alternative diagnostic tool, evidence for its clinical benefit is lacking. Objective To determine
if BAL-directed therapy for pulmonary exacerbations during the first 5 years of life provides
better outcomes than current standard practice relying on clinical features and …
