Function of PU. 1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters
DE Zhang, S Hohaus, MT Voso, HM Chen… - Molecular Aspects of …, 1996 - Springer
DE Zhang, S Hohaus, MT Voso, HM Chen, LT Smith, CJ Hetherington, DG Tenen
Molecular Aspects of Myeloid Stem Cell Development, 1996•SpringerRecent studies of the regulation of normal myeloid genes, as well as the study of leukemias,
has suggested that transcription factors play a major role in hematopoietic differentiation as
well as leukemogenesis.[l–3] In order to understand the process of normal myeloid
differentiation, it is important to identify and characterize the transcription factors which
specifically activate important genes in the myeloid lineage. In addition, these factors may
play a role in acute myelogenous leukemia (AML), in which this normal differentiation …
has suggested that transcription factors play a major role in hematopoietic differentiation as
well as leukemogenesis.[l–3] In order to understand the process of normal myeloid
differentiation, it is important to identify and characterize the transcription factors which
specifically activate important genes in the myeloid lineage. In addition, these factors may
play a role in acute myelogenous leukemia (AML), in which this normal differentiation …
Abstract
Recent studies of the regulation of normal myeloid genes, as well as the study of leukemias, has suggested that transcription factors play a major role in hematopoietic differentiation as well as leukemogenesis.[l–3] In order to understand the process of normal myeloid differentiation, it is important to identify and characterize the transcription factors which specifically activate important genes in the myeloid lineage. In addition, these factors may play a role in acute myelogenous leukemia (AML), in which this normal differentiation program is blocked. Receptors for growth factors play an important role in myelopoiesis. [4–7] In order to further understand the mechanisms directing the expression of these key regulators of hematopoiesis, we have initiated studies investigating the transcription factors activating the expression of several important myeloid colony-stimulating factor (CSF) receptors.
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