[HTML][HTML] CD44 promotes chemoresistance in T-ALL by increased drug efflux
C Hoofd, X Wang, S Lam, C Jenkins, B Wood… - Experimental …, 2016 - Elsevier
Highlights•Chemotherapy selected for increased CD44 expression in a mouse model of T-
cell acute lymphoblastic leukemia (T-ALL).•Enforced CD44 expression in mouse and human
T-ALL cells enhanced chemoresistance.•CD44 knockdown or treatment with blocking
antibody enhanced chemosensitivity.•CD44 enhanced drug efflux activity in human T-ALL
cells.•Patients undergoing induction chemotherapy had elevated CD44 levels in residual
blasts.T-Cell acute lymphoblastic leukemia is considered a largely curable disease in …
cell acute lymphoblastic leukemia (T-ALL).•Enforced CD44 expression in mouse and human
T-ALL cells enhanced chemoresistance.•CD44 knockdown or treatment with blocking
antibody enhanced chemosensitivity.•CD44 enhanced drug efflux activity in human T-ALL
cells.•Patients undergoing induction chemotherapy had elevated CD44 levels in residual
blasts.T-Cell acute lymphoblastic leukemia is considered a largely curable disease in …
