Background: Hyaluronan (HA) contributes to the extracellular matrix in bone marrow.
Results: HA expressed by the hematopoietic microenvironment supports hematopoiesis and
is involved in hematopoietic stem/progenitor cell migration by regulating the production of
soluble factors. Conclusion: Endogenous HA is an important regulatory element of the
hematopoietic microenvironment. Significance: Understanding the biology of HA may help to
develop strategies for improving the quality of the stem cell microenvironment.