Lung volume, pulmonary vasculature, and factors affecting survival in congenital diaphragmatic hernia

DW Thibeault, B Haney - Pediatrics, 1998 - publications.aap.org
Objectives. There is a wide variation in published mortality from congenital diaphragmatic
hernia (CDH). The prevailing opinion is that this variation is related directly to the degree of
pulmonary hypoplasia. Our aim was to test the hypothesis that other factors are important for
outcome. The specific objectives of this study were: 1) to quantitate the degree of lung
hypoplasia and pulmonary arterial wall thickness in infants eligible for, and treated with,
extracorporeal membrane oxygenation (ECMO), using postmortem analysis of lung DNA …