Netrin-1 as a guidance molecule in the postnatal rat cochlea
LN Gillespie, PL Marzella, GM Clark, JM Crook - Hearing research, 2005 - Elsevier
During synaptogenesis a number of growth factors and peptides control the guidance of
auditory neuron (spiral ganglion neuron, SGN) axons to their target cells. Furthermore,
evidence suggests that these factors exert their actions at discrete times and sites during
development. This study demonstrates that the guidance molecule netrin-1 is expressed in
the early postnatal rat cochlea, but shows decreasing expression with increasing age. These
results suggest that netrin-1 may be involved in guiding axonal growth from SGNs for the …
auditory neuron (spiral ganglion neuron, SGN) axons to their target cells. Furthermore,
evidence suggests that these factors exert their actions at discrete times and sites during
development. This study demonstrates that the guidance molecule netrin-1 is expressed in
the early postnatal rat cochlea, but shows decreasing expression with increasing age. These
results suggest that netrin-1 may be involved in guiding axonal growth from SGNs for the …