[HTML][HTML] Epiregulin is a potent pan-ErbB ligand that preferentially activates heterodimeric receptor complexes

M Shelly, R Pinkas-Kramarski, BC Guarino… - Journal of Biological …, 1998 - ASBMB
The ErbB signaling network consists of four transmembrane receptor tyrosine kinases and
more than a dozen ligands sharing an epidermal growth factor (EGF) motif. The multiplicity
of ErbB-specific ligands is incompletely understood in terms of signal specificity because all
ErbB molecules signal through partially overlapping pathways. Here we addressed the
action of epiregulin, a recently isolated ligand of ErbB-1. By employing a set of factor-
dependent cell lines engineered to express individual ErbBs or their combinations, we found …