[HTML][HTML] Cigarette smoke exposure hinders long-term allograft survival by suppressing indoleamine 2, 3-dioxygenase expression

F Wan, H Dai, S Zhang, Y Moore, N Wan… - American Journal of …, 2012 - Elsevier
Cigarette smoke causes cancer and increases the vulnerability of smokers to infections.
Epidemiologic studies have shown that smoking is one of major risk factors for late allograft
rejection. Despite statistical data that associate smoking with allograft rejection, no any study
has been conducted to prove that cigarette smoke directly causes allograft rejection in a
cause–effect manner. In particular, investigation into immunologic mechanisms underlying
smoke-related allograft rejection is lacking. Here we found that second hand smoke (SHS) …