[PDF][PDF] The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain
Summary TTF-1, a homeodomain-containing transcription factor, which is required for the
specific expression of the thyroglobulin and thyroperoxidase gene promoters in
differentiated thyroid cell lines, is expressed at the very beginning of rat thyroid
differentiation. TTF-1 mRNA is detected in the endodermal cells of the thyroid rudiment in the
rat embryo and precedes the expression of the two known target genes by 5 days. No delay
is observed between the appearance of TTF-1 mRNA and protein, which shows a clear …
specific expression of the thyroglobulin and thyroperoxidase gene promoters in
differentiated thyroid cell lines, is expressed at the very beginning of rat thyroid
differentiation. TTF-1 mRNA is detected in the endodermal cells of the thyroid rudiment in the
rat embryo and precedes the expression of the two known target genes by 5 days. No delay
is observed between the appearance of TTF-1 mRNA and protein, which shows a clear …
Summary
TTF-1, a homeodomain-containing transcription factor, which is required for the specific expression of the thyroglobulin and thyroperoxidase gene promoters in differentiated thyroid cell lines, is expressed at the very beginning of rat thyroid differentiation. TTF-1 mRNA is detected in the endodermal cells of the thyroid rudiment in the rat embryo and precedes the expression of the two known target genes by 5 days. No delay is observed between the appearance of TTF-1 mRNA and protein, which shows a clear nuclear localization. In the adult thyroid, TTF-1 is present only in the endoderm-derived follicular cells.
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