[HTML][HTML] Carbohydrate vaccines: developing sweet solutions to sticky situations?

RD Astronomo, DR Burton - Nature reviews Drug discovery, 2010 - nature.com
RD Astronomo, DR Burton
Nature reviews Drug discovery, 2010nature.com
Recent technological advances in glycobiology and glycochemistry are paving the way for a
new era in carbohydrate vaccine design. This is enabling greater efficiency in the
identification, synthesis and evaluation of unique glycan epitopes found on a plethora of
pathogens and malignant cells. Here, we review the progress being made in addressing
challenges posed by targeting the surface carbohydrates of bacteria, protozoa, helminths,
viruses, fungi and cancer cells for vaccine purposes.
Abstract
Recent technological advances in glycobiology and glycochemistry are paving the way for a new era in carbohydrate vaccine design. This is enabling greater efficiency in the identification, synthesis and evaluation of unique glycan epitopes found on a plethora of pathogens and malignant cells. Here, we review the progress being made in addressing challenges posed by targeting the surface carbohydrates of bacteria, protozoa, helminths, viruses, fungi and cancer cells for vaccine purposes.
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