[HTML][HTML] Activation of autoreactive B cells by endogenous TLR7 and TLR3 RNA ligands

NM Green, KS Moody, M Debatis… - Journal of Biological …, 2012 - ASBMB
The key step in the activation of autoreactive B cells is the internalization of nucleic acid
containing ligands and delivery of these ligands to the Toll-like Receptor (TLR) containing
endolysosomal compartment. Ribonucleoproteins represent a large fraction of autoantigens
in systemic autoimmune diseases. Here we demonstrate that many uridine-rich mammalian
RNA sequences associated with common autoantigens effectively activate autoreactive B
cells. Priming with type I IFN increased the magnitude of activation, and the range of which …