Paraspeckles

AH Fox, AI Lamond - Cold Spring Harbor perspectives in …, 2010 - cshperspectives.cshlp.org
Cold Spring Harbor perspectives in biology, 2010cshperspectives.cshlp.org
Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin
space of mammalian cells. They are RNA-protein structures formed by the interaction
between a long nonprotein-coding RNA species, NEAT1/Men ε/β, and members of the
DBHS (Drosophila Behavior Human Splicing) family of proteins: P54NRB/NONO, PSPC1,
and PSF/SFPQ. Paraspeckles are critical to the control of gene expression through the
nuclear retention of RNA containing double-stranded RNA regions that have been subject to …
Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin space of mammalian cells. They are RNA-protein structures formed by the interaction between a long nonprotein-coding RNA species, NEAT1/Men ε/β, and members of the DBHS (Drosophila Behavior Human Splicing) family of proteins: P54NRB/NONO, PSPC1, and PSF/SFPQ. Paraspeckles are critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing. Through this mechanism paraspeckles and their components may ultimately have a role in controlling gene expression during many cellular processes including differentiation, viral infection, and stress responses.
cshperspectives.cshlp.org