[HTML][HTML] An update on the biology of sphingosine 1-phosphate receptors

VA Blaho, T Hla - Journal of lipid research, 2014 - ASBMB
Sphingosine 1-phosphate (S1P) is a membrane-derived lysophospholipid that acts primarily
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G
protein-coupled receptors, named S1P 1–5. Cellular and temporal expression of the S1P
receptors (S1PRs) determine their specific roles in various organ systems, but they are
particularly critical for regulation of the cardiovascular, immune, and nervous systems, with
the most well-known contributions of S1PR signaling being modulation of vascular barrier …