[HTML][HTML] Resting energy expenditure is decreased in pseudohypoparathyroidism type 1A

JD Roizen, J Danzig, V Groleau… - The Journal of clinical …, 2016 - ncbi.nlm.nih.gov
JD Roizen, J Danzig, V Groleau, S McCormack, A Casella, J Harrington, E Sochett…
The Journal of clinical endocrinology and metabolism, 2016ncbi.nlm.nih.gov
Objective: The aim of this study was to evaluate resting energy expenditure (REE) in
participants with PHP1A. Design: We assessed REE, biochemical, endocrine, and
auxological status of 12 participants with PHP1A who had normal or elevated body mass
index; controls were a cohort of 156 obese participants. Setting: This study took place at
Children's Hospital in Philadelphia and Sick Children's Hospital in Toronto. Main Outcome
Measures: REE as a percent of predicted REE was the outcome measure. Results: PHP1A …
Objective:
The aim of this study was to evaluate resting energy expenditure (REE) in participants with PHP1A.
Design:
We assessed REE, biochemical, endocrine, and auxological status of 12 participants with PHP1A who had normal or elevated body mass index; controls were a cohort of 156 obese participants.
Setting:
This study took place at Children's Hospital in Philadelphia and Sick Children's Hospital in Toronto.
Main Outcome Measures:
REE as a percent of predicted REE was the outcome measure.
Results:
PHP1A participants had normal endocrine status while receiving appropriate hormone replacement therapy, but had significantly decreased REE as a percent of predicted REE (using the modified Schofield equation).
Conclusion:
Our results are consistent with REE being the principal cause of obesity in PHP1A rather than it being caused by excessive energy intake or endocrine dysfunction.
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