IL-13 and the IL-13 receptor as therapeutic targets for asthma and allergic disease.
J Mitchell, V Dimov, RG Townley - Current opinion in investigational …, 2010 - europepmc.org
J Mitchell, V Dimov, RG Townley
Current opinion in investigational drugs (London, England: 2000), 2010•europepmc.orgIt is widely accepted that T-helper 2 cell (Th2) cytokines play an important role in the
maintenance of asthma and allergy. Emerging evidence has highlighted the role of IL-13 in
the pathogenesis of these diseases. In particular, IL-13 is involved in the regulation of IgE
synthesis, mucus hypersecretion, subepithelial fibrosis and eosinophil infiltration, and has
been associated with the regulation of certain chemokine receptors, notably CCR5. Thus,
targeting IL-13 and its associated receptors may be a therapeutic approach to the treatment …
maintenance of asthma and allergy. Emerging evidence has highlighted the role of IL-13 in
the pathogenesis of these diseases. In particular, IL-13 is involved in the regulation of IgE
synthesis, mucus hypersecretion, subepithelial fibrosis and eosinophil infiltration, and has
been associated with the regulation of certain chemokine receptors, notably CCR5. Thus,
targeting IL-13 and its associated receptors may be a therapeutic approach to the treatment …
It is widely accepted that T-helper 2 cell (Th2) cytokines play an important role in the maintenance of asthma and allergy. Emerging evidence has highlighted the role of IL-13 in the pathogenesis of these diseases. In particular, IL-13 is involved in the regulation of IgE synthesis, mucus hypersecretion, subepithelial fibrosis and eosinophil infiltration, and has been associated with the regulation of certain chemokine receptors, notably CCR5. Thus, targeting IL-13 and its associated receptors may be a therapeutic approach to the treatment of asthma and/or allergy. Pharmaceutical and biotechnology companies are researching various strategies, based on this approach, aimed at binding IL-13, increasing the level of the IL-13 decoy receptor, IL-13Ralpha2, or blocking the effect of the chemokine receptor CCR5. This review focuses on the therapeutic potential of anti-IL-13 agents and their role in the treatment of asthma and allergy.
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