Antioxidants for chronic kidney disease

M Jun, V Venkataraman, M Razavian… - Cochrane Database …, 2012 - cochranelibrary.com
M Jun, V Venkataraman, M Razavian, B Cooper, S Zoungas, T Ninomiya, AC Webster
Cochrane Database of Systematic Reviews, 2012cochranelibrary.com
Background Chronic kidney disease (CKD) is a significant risk factor for premature
cardiovascular disease and death. Increased oxidative stress in people with CKD has been
implicated as a potential causative factor for some cardiovascular diseases. Antioxidant
therapy may reduce cardiovascular mortality and morbidity in people with CKD. Objectives
To examine the benefits and harms of antioxidant therapy on mortality and cardiovascular
events in people with CKD stages 3 to 5; dialysis, and kidney transplantation patients.
Background
Chronic kidney disease (CKD) is a significant risk factor for premature cardiovascular disease and death. Increased oxidative stress in people with CKD has been implicated as a potential causative factor for some cardiovascular diseases. Antioxidant therapy may reduce cardiovascular mortality and morbidity in people with CKD.
Objectives
To examine the benefits and harms of antioxidant therapy on mortality and cardiovascular events in people with CKD stages 3 to 5; dialysis, and kidney transplantation patients.
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