[HTML][HTML] Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems
T Tasaki, R Sohr, Z Xia, R Hellweg, H Hortnagl… - Journal of Biological …, 2007 - ASBMB
Our previous work identified E3 ubiquitin ligases, termed UBR1-UBR7, that contain the∼ 70-
residue UBR box, a motif important for the targeting of N-end rule substrates. In this pathway,
specific N-terminal residues of substrates are recognized as degradation signals by UBR
box-containing E3s that include UBR1, UBR2, UBR4, and UBR5. The other E3s of this set,
UBR3, UBR6, and UBR7, remained uncharacterized. Here we describe the cloning and
analyses of mouse UBR3. The similarities of UBR3 to the UBR1 and UBR2 E3s of the N-end …
residue UBR box, a motif important for the targeting of N-end rule substrates. In this pathway,
specific N-terminal residues of substrates are recognized as degradation signals by UBR
box-containing E3s that include UBR1, UBR2, UBR4, and UBR5. The other E3s of this set,
UBR3, UBR6, and UBR7, remained uncharacterized. Here we describe the cloning and
analyses of mouse UBR3. The similarities of UBR3 to the UBR1 and UBR2 E3s of the N-end …