Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome
MD Gershon - Journal of clinical gastroenterology, 2005 - journals.lww.com
The bowel exhibits reflexes in the absence of CNS input. To do so, epithelial sensory
transducers, such as enterochromaffin (EC) cells, activate the mucosal processes of intrinsic
(IPANs) and extrinsic primary afferent (sensory) neurons. EC cells secrete serotonin (5-HT)
in response to mucosal stimuli. Submucosal IPANs, which secrete acetylcholine and
calcitonin gene-related peptide, initiate peristaltic and secretory reflexes and are activated
via “5-HT 1P” receptors. Release of neurotransmitters is enhanced by 5-HT 4 receptors …
transducers, such as enterochromaffin (EC) cells, activate the mucosal processes of intrinsic
(IPANs) and extrinsic primary afferent (sensory) neurons. EC cells secrete serotonin (5-HT)
in response to mucosal stimuli. Submucosal IPANs, which secrete acetylcholine and
calcitonin gene-related peptide, initiate peristaltic and secretory reflexes and are activated
via “5-HT 1P” receptors. Release of neurotransmitters is enhanced by 5-HT 4 receptors …