Mechanisms of hypoxia responses in renal tissue

VH Haase - Journal of the american society of nephrology, 2013 - journals.lww.com
Abstract pO 2 in the kidney is maintained at relatively stable levels by a unique and complex
functional interplay between renal blood flow, GFR, O 2 consumption, and arteriovenous O 2
shunting. The fragility of this interplay makes the kidney susceptible to hypoxic injury. Cells
in the kidney utilize various molecular pathways that allow them to respond and adapt to
changes in renal oxygenation. This review provides an integrative perspective on the role of
molecular hypoxia responses in normal kidney physiology and pathophysiology, and …