[HTML][HTML] Carbon monoxide modulates apoptosis by reinforcing oxidative metabolism in astrocytes
AS Almeida, CSF Queiroga, MFQ Sousa… - Journal of Biological …, 2012 - ASBMB
Modulation of cerebral cell metabolism for improving the outcome of hypoxia-ischemia and
reperfusion is a strategy yet to be explored. Because carbon monoxide (CO) is known to
prevent cerebral cell death; herein the role of CO in the modulation of astrocytic metabolism,
in particular, at the level of mitochondria was investigated. Low concentrations of CO
partially inhibited oxidative stress-induced apoptosis in astrocytes, by preventing caspase-3
activation, mitochondrial potential depolarization, and plasmatic membrane permeability …
reperfusion is a strategy yet to be explored. Because carbon monoxide (CO) is known to
prevent cerebral cell death; herein the role of CO in the modulation of astrocytic metabolism,
in particular, at the level of mitochondria was investigated. Low concentrations of CO
partially inhibited oxidative stress-induced apoptosis in astrocytes, by preventing caspase-3
activation, mitochondrial potential depolarization, and plasmatic membrane permeability …
