Induction of heme oxygenase-1 in the donor reduces graft immunogenicity
PNA Martins, H Kessler, A Jurisch… - Transplantation …, 2005 - Elsevier
There is increasing evidence that the induction of the enzyme heme oxygenase-1 (HO-1)
improves both graft function and survival. Although it has been shown that HO-1 promotes
graft protection, it remains unknown whether it reduces graft immunogenicity by modulating
dendritic cells. In the current experiment, we investigated the impact of HO-1 induction on
frequencies and trafficking of donor-derived dendritic cells (DCs). Kidneys from DA rats were
transplanted into untreated Lewis recipients. Donor animals were treated with cobalt …
improves both graft function and survival. Although it has been shown that HO-1 promotes
graft protection, it remains unknown whether it reduces graft immunogenicity by modulating
dendritic cells. In the current experiment, we investigated the impact of HO-1 induction on
frequencies and trafficking of donor-derived dendritic cells (DCs). Kidneys from DA rats were
transplanted into untreated Lewis recipients. Donor animals were treated with cobalt …