Beyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesis
Fibroblast growth factor (FGF) signaling regulates cell proliferation, differentiation, survival,
angiogenesis, and wound healing. Compelling evidence for deregulated FGF signaling in
tumorigenesis continues to emerge, and a growing body of research suggests that FGF may
also play an integral role in the resistance to anti-VEGF therapy. Although agents targeting
FGF signaling are early in development, the potential to target both the VEGF and FGF
pathways may translate into improvements in the clinical care of cancer patients. Clin …
angiogenesis, and wound healing. Compelling evidence for deregulated FGF signaling in
tumorigenesis continues to emerge, and a growing body of research suggests that FGF may
also play an integral role in the resistance to anti-VEGF therapy. Although agents targeting
FGF signaling are early in development, the potential to target both the VEGF and FGF
pathways may translate into improvements in the clinical care of cancer patients. Clin …
Abstract
Fibroblast growth factor (FGF) signaling regulates cell proliferation, differentiation, survival, angiogenesis, and wound healing. Compelling evidence for deregulated FGF signaling in tumorigenesis continues to emerge, and a growing body of research suggests that FGF may also play an integral role in the resistance to anti-VEGF therapy. Although agents targeting FGF signaling are early in development, the potential to target both the VEGF and FGF pathways may translate into improvements in the clinical care of cancer patients. Clin Cancer Res; 17(19); 6130–9. ©2011 AACR.
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