Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation …
K Ichikawa, T Noda, Y Furuichi - Nihon yakurigaku zasshi. Folia …, 2002 - europepmc.org
K Ichikawa, T Noda, Y Furuichi
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2002•europepmc.orgThe list of human RecQ helicase comprises RecQ1, BLM (Bloom syndrome), WRN (Werner
syndrome), RTS (Rothmund-Thomson syndrome), and RecQ5. Of these, the defective BLM,
WRN, and RTS helicases are responsible for distinct but overlapping clinical features
suggesting premature aging and an enhanced risk of cancer, which apparently stems from
chromosomal instability in the cells of tissues and organs where expression of the helicase
genes are specified. In an effort to obtain an animal model for these diseases, we performed …
syndrome), RTS (Rothmund-Thomson syndrome), and RecQ5. Of these, the defective BLM,
WRN, and RTS helicases are responsible for distinct but overlapping clinical features
suggesting premature aging and an enhanced risk of cancer, which apparently stems from
chromosomal instability in the cells of tissues and organs where expression of the helicase
genes are specified. In an effort to obtain an animal model for these diseases, we performed …
The list of human RecQ helicase comprises RecQ1, BLM (Bloom syndrome), WRN (Werner syndrome), RTS (Rothmund-Thomson syndrome), and RecQ5. Of these, the defective BLM, WRN, and RTS helicases are responsible for distinct but overlapping clinical features suggesting premature aging and an enhanced risk of cancer, which apparently stems from chromosomal instability in the cells of tissues and organs where expression of the helicase genes are specified. In an effort to obtain an animal model for these diseases, we performed gene target experiments to generate the WRN and RTS knockout mice.
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