Effects of radiation on wound healing.
Q Gu, D Wang, C Cui, Y Gao, G Xia… - Journal of Environmental …, 1998 - europepmc.org
Q Gu, D Wang, C Cui, Y Gao, G Xia, X Cui
Journal of Environmental Pathology, Toxicology and Oncology: Official …, 1998•europepmc.orgThe pathological changes of radiation on wound healing in rats were observed by
macroscopic, microscopic, and electronmicroscopic examination and detection of collagen
types. We found that the wound healing process was obviously delayed by irradiation. First,
the early phase inflammatory response was severely inhibited. In particular, the number of
infiltrating macrophages and neutrophils was decreased, blood vessels were injured, and
hemorrhage was evident. Second, the formation and maturation of granulation tissue were …
macroscopic, microscopic, and electronmicroscopic examination and detection of collagen
types. We found that the wound healing process was obviously delayed by irradiation. First,
the early phase inflammatory response was severely inhibited. In particular, the number of
infiltrating macrophages and neutrophils was decreased, blood vessels were injured, and
hemorrhage was evident. Second, the formation and maturation of granulation tissue were …
The pathological changes of radiation on wound healing in rats were observed by macroscopic, microscopic, and electronmicroscopic examination and detection of collagen types. We found that the wound healing process was obviously delayed by irradiation. First, the early phase inflammatory response was severely inhibited. In particular, the number of infiltrating macrophages and neutrophils was decreased, blood vessels were injured, and hemorrhage was evident. Second, the formation and maturation of granulation tissue were slowed down, fibroblasts were injured, and transcription of types and collagen mRNAs and synthesis and secretion of collagen were reduced. Finally, the reepithelialization process was delayed and the healing time was prolonged.
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