[HTML][HTML] Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells
S Zhaorigetu, Z Yang, I Toma, TA McCaffrey… - Journal of Biological …, 2011 - ASBMB
Inflammatory cytokine-regulated apoptosis and autophagy play pivotal roles in plaque
rupture and thrombosis of atherosclerotic lesions. However, the molecular interplay between
apoptosis and autophagy in vascular cells has not been investigated. Our prior study
showed that human apolipoprotein L6 (ApoL6), a pro-apoptotic BH3-only member of the Bcl-
2 family, was one of the downstream targets of interferon-γ (INFγ), which sensitizes
atherosclerotic lesion-derived cells (LDCs) to Fas-induced apoptosis. To investigate whether …
rupture and thrombosis of atherosclerotic lesions. However, the molecular interplay between
apoptosis and autophagy in vascular cells has not been investigated. Our prior study
showed that human apolipoprotein L6 (ApoL6), a pro-apoptotic BH3-only member of the Bcl-
2 family, was one of the downstream targets of interferon-γ (INFγ), which sensitizes
atherosclerotic lesion-derived cells (LDCs) to Fas-induced apoptosis. To investigate whether …