Paclitaxel (Taxol®) is one of the most effective and frequently used chemotherapeutics for
the treatment of solid tumours. However, paclitaxel produces peripheral neurotoxicity with
patients reporting sensory abnormalities and neuropathic pain during and often persisting
after paclitaxel therapy. The mechanisms underlying this dose-limiting side effect are
currently unknown and there are no validated drugs for its prevention or control. Male
Sprague–Dawley rats received four intraperitoneal (ip) injections on alternate days of 2 …