The 67 and 65 kDa isoforms of glutamic acid decarboxylase, the key enzymes for GABA
biosynthesis, are expressed at altered levels in postmortem brain of subjects diagnosed with
schizophrenia and related disorders, including autism and bipolar illness. The predominant
finding is a decrease in GAD67 mRNA levels, affecting multiple brain regions, including
prefrontal and temporal cortex. Postmortem studies, in conjunction with animal models,
identified several mechanisms that contribute to the dysregulation of GAD67 in cerebral …