[HTML][HTML] Crucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17
XK Liu, X Lin, SL Gaffen - Journal of Biological Chemistry, 2004 - ASBMB
The biological activities of the inflammatory cytokine interleukin (IL)-17 have been widely
studied. However, comparatively little is known about how IL-17 expression is controlled.
Here, we examined the basis for transcriptional regulation of the human IL-17 gene. IL-17
secretion was induced in peripheral blood mononuclear cells following anti-CD3 cross-
linking to activate the T cell receptor (TCR), and costimulatory signaling through CD28
strongly enhanced CD3-induced IL-17 production. To define cis-acting elements important …
studied. However, comparatively little is known about how IL-17 expression is controlled.
Here, we examined the basis for transcriptional regulation of the human IL-17 gene. IL-17
secretion was induced in peripheral blood mononuclear cells following anti-CD3 cross-
linking to activate the T cell receptor (TCR), and costimulatory signaling through CD28
strongly enhanced CD3-induced IL-17 production. To define cis-acting elements important …