A change in intracellular free calcium is a common signaling mechanism that modulates a
wide array of physiological processes in most cells. Responses to increased intracellular
Ca2+ are often mediated by the ubiquitous protein calmodulin (CaM) that upon binding
Ca2+ can interact with and alter the functionality of numerous proteins including a family of
protein kinases referred to as CaM-kinases (CaMKs). Of particular interest are
multifunctional CaMKs, such as CaMKI, CaMKII, CaMKIV and CaMKK, that can …