Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections
G Senti, R Crameri, D Kuster, P Johansen… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Subcutaneous allergen-specific immunotherapy frequently causes allergic
side effects and requires 30 to 80 injections over 3 to 5 years. OBJECTIVE: We sought to
improve immunotherapy by using intralymphatic allergen administration (intralymphatic
immunotherapy [ILIT]) and by targeting allergen to the MHC class II pathway. METHODS:
Recombinant major cat dander allergen Fel d 1 was fused to a translocation sequence (TAT)
and to part of the human invariant chain, generating a modular antigen transporter (MAT) …
side effects and requires 30 to 80 injections over 3 to 5 years. OBJECTIVE: We sought to
improve immunotherapy by using intralymphatic allergen administration (intralymphatic
immunotherapy [ILIT]) and by targeting allergen to the MHC class II pathway. METHODS:
Recombinant major cat dander allergen Fel d 1 was fused to a translocation sequence (TAT)
and to part of the human invariant chain, generating a modular antigen transporter (MAT) …