Efficacy of combination treatment with anti-IgE plus specific immunotherapy in polysensitized children and adolescents with seasonal allergic rhinitis
J Kuehr, J Brauburger, S Zielen, U Schauer… - Journal of Allergy and …, 2002 - Elsevier
Background: Specific immunotherapy (SIT) and treatment with monoclonal anti-IgE antibody
have complementary modes of action. Objective: The purpose of this study was to determine
whether combined therapy could provide better efficacy than either treatment alone.
Methods: We conducted a randomized, double-blinded trial to assess the efficacy and safety
of subcutaneously administered anti-IgE (omalizumab) or placebo in children and
adolescents with seasonal allergic rhinitis in both a birch pollen season and a grass pollen …
have complementary modes of action. Objective: The purpose of this study was to determine
whether combined therapy could provide better efficacy than either treatment alone.
Methods: We conducted a randomized, double-blinded trial to assess the efficacy and safety
of subcutaneously administered anti-IgE (omalizumab) or placebo in children and
adolescents with seasonal allergic rhinitis in both a birch pollen season and a grass pollen …