Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy
JH Savage, JP Courneya, PM Sterba… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Monoclonal antibodies directed at IgE demonstrate clinical efficacy in
subjects with peanut allergy, but previous studies have not addressed the kinetics of the
clinical response or the role of mast cells and basophils in the food-induced allergic
response. OBJECTIVE: We sought to determine the kinetics of the clinical response to
omalizumab and whether clinical improvement is associated with either mast cell or
basophil suppression. METHODS: Subjects with peanut allergy were treated with …
subjects with peanut allergy, but previous studies have not addressed the kinetics of the
clinical response or the role of mast cells and basophils in the food-induced allergic
response. OBJECTIVE: We sought to determine the kinetics of the clinical response to
omalizumab and whether clinical improvement is associated with either mast cell or
basophil suppression. METHODS: Subjects with peanut allergy were treated with …