Antigen-specific T cell–mediated apoptosis of dendritic cells is impaired in a mouse model of food allergy
AL Man, E Bertelli, M Regoli, SJ Chambers… - Journal of allergy and …, 2004 - Elsevier
BACKGROUND: Dendritic cells (DCs) play a pivotal role in antigen presentation and
regulation of immune responses, and strong evidence suggests their involvement in the
pathogenesis of allergy. However, hitherto, DC–T-cell cross-talk in relation to IgE-mediated
allergic reactions to food has not been investigated. OBJECTIVE: Our aim was to investigate
T cell–mediated apoptosis of myeloid DCs from spleen and Peyer's patches of mice with
cow's milk (CM) allergy after cognate interaction with antigen (CM)–specific T cells …
regulation of immune responses, and strong evidence suggests their involvement in the
pathogenesis of allergy. However, hitherto, DC–T-cell cross-talk in relation to IgE-mediated
allergic reactions to food has not been investigated. OBJECTIVE: Our aim was to investigate
T cell–mediated apoptosis of myeloid DCs from spleen and Peyer's patches of mice with
cow's milk (CM) allergy after cognate interaction with antigen (CM)–specific T cells …