Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy
M Worm, HH Lee, J Kleine-Tebbe, RP Hafner… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Allergic sensitization to cat allergens is common and represents a major
risk factor for asthma. Specific immunotherapy (SIT) is effective but cumbersome and
associated with IgE-dependent adverse events. Immunotherapy targeting allergen-specific T
cells, with synthetic peptides representing T-cell epitopes, might improve safety and reduce
the duration of treatment. OBJECTIVE: We sought to define major T-cell epitopes of Fel d 1
for peptide immunotherapy, generate a peptide vaccine, and evaluate its safety and …
risk factor for asthma. Specific immunotherapy (SIT) is effective but cumbersome and
associated with IgE-dependent adverse events. Immunotherapy targeting allergen-specific T
cells, with synthetic peptides representing T-cell epitopes, might improve safety and reduce
the duration of treatment. OBJECTIVE: We sought to define major T-cell epitopes of Fel d 1
for peptide immunotherapy, generate a peptide vaccine, and evaluate its safety and …