Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles
CM Boomsma, MS Kamath, SD Keay… - Cochrane Database …, 2022 - cochranelibrary.com
CM Boomsma, MS Kamath, SD Keay, NS Macklon
Cochrane Database of Systematic Reviews, 2022•cochranelibrary.comBackground The use of peri‐implantation glucocorticoids has been advocated to improve
embryo implantation during assistive reproductive technology (ART) cycles such as in vitro
fertilisation (IVF) or intracytoplasmic sperm injection (ICSI). It has been proposed that
glucocorticoids may improve the intrauterine environment by acting as immunomodulators to
reduce the uterine natural killer (NK) cell count and activity, normalising the cytokine
expression profile in the endometrium and by suppression of endometrial inflammation …
embryo implantation during assistive reproductive technology (ART) cycles such as in vitro
fertilisation (IVF) or intracytoplasmic sperm injection (ICSI). It has been proposed that
glucocorticoids may improve the intrauterine environment by acting as immunomodulators to
reduce the uterine natural killer (NK) cell count and activity, normalising the cytokine
expression profile in the endometrium and by suppression of endometrial inflammation …
Background
The use of peri‐implantation glucocorticoids has been advocated to improve embryo implantation during assistive reproductive technology (ART) cycles such as in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI). It has been proposed that glucocorticoids may improve the intrauterine environment by acting as immunomodulators to reduce the uterine natural killer (NK) cell count and activity, normalising the cytokine expression profile in the endometrium and by suppression of endometrial inflammation.
Objectives
To evaluate the effectiveness and safety of glucocorticoids versus no glucocorticoids administered around the time of anticipated implantation in women undergoing IVF or ICSI.
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