Early human decidual cells exhibit NK activity against the K562 cell line but not against first trimester trophoblast
A King, C Birkby, YW Loke - Cellular immunology, 1989 - Elsevier
The susceptibility of cultured first trimester human trophoblast cells to lysis by NK cells has
been studied. Trophoblast cells are resistant to lysis by NK cells from both peripheral blood
and decidua. However, decidual cells extracted by enzymatic disaggregation do exhibit
cytotoxicity against the NK-sensitive cell line K562. The relevance of these findings to
successful implantation of the blastocyst is discussed.
been studied. Trophoblast cells are resistant to lysis by NK cells from both peripheral blood
and decidua. However, decidual cells extracted by enzymatic disaggregation do exhibit
cytotoxicity against the NK-sensitive cell line K562. The relevance of these findings to
successful implantation of the blastocyst is discussed.
