[HTML][HTML] mRNA localization: gene expression in the spatial dimension
KC Martin, A Ephrussi - Cell, 2009 - cell.com
KC Martin, A Ephrussi
Cell, 2009•cell.comThe localization of mRNAs to subcellular compartments provides a mechanism for
regulating gene expression with exquisite temporal and spatial control. Recent studies
suggest that a large fraction of mRNAs localize to distinct cytoplasmic domains. In this
Review, we focus on cis-acting RNA localization elements, RNA-binding proteins, and the
assembly of mRNAs into granules that are transported by molecular motors along
cytoskeletal elements to their final destination in the cell.
regulating gene expression with exquisite temporal and spatial control. Recent studies
suggest that a large fraction of mRNAs localize to distinct cytoplasmic domains. In this
Review, we focus on cis-acting RNA localization elements, RNA-binding proteins, and the
assembly of mRNAs into granules that are transported by molecular motors along
cytoskeletal elements to their final destination in the cell.
The localization of mRNAs to subcellular compartments provides a mechanism for regulating gene expression with exquisite temporal and spatial control. Recent studies suggest that a large fraction of mRNAs localize to distinct cytoplasmic domains. In this Review, we focus on cis-acting RNA localization elements, RNA-binding proteins, and the assembly of mRNAs into granules that are transported by molecular motors along cytoskeletal elements to their final destination in the cell.
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