Bone resorption is closely dependent on osteoclastic survival and osteoclast apoptotic cell
death could represent a key step at the end of this process. In order to precise the possible
role of calcium movement in osteoclastic cell death, we investigated whether intracellular
calcium store replenishment and capacitive calcium entry (CCE) are involved in osteoclastic
survival and bone resorption. We demonstrate that (i) thapsigargin, a sarco-endoplasmic
reticulum calcium ATPase pump (SERCA) blocker, decreases both osteoclastic survival and …