Association between plasma free haem and incidence of vaso‐occlusive episodes and acute chest syndrome in children with sickle cell disease
OA Adisa, Y Hu, S Ghosh, D Aryee… - British journal of …, 2013 - Wiley Online Library
OA Adisa, Y Hu, S Ghosh, D Aryee, I Osunkwo, SF Ofori‐Acquah
British journal of haematology, 2013•Wiley Online LibraryWe tested the hypothesis that extracellular haem is linked to the incidence of acute
complications of sickle cell disease (SCD). Using multivariable regression analysis, higher
plasma free haem, but not total plasma haem, was associated with increased odds of vaso‐
occlusive crisis (VOC)[P= 0· 028, odds ratio (OR); 2· 05, 95% Confidence Interval (CI)= 1· 08–
3· 89] and acute chest syndrome (ACS)[P= 0· 016, OR; 2· 56, CI= 1· 19, 5· 47], after adjusting
for age and gender in children with SCD. These findings suggest that haem and factors that …
complications of sickle cell disease (SCD). Using multivariable regression analysis, higher
plasma free haem, but not total plasma haem, was associated with increased odds of vaso‐
occlusive crisis (VOC)[P= 0· 028, odds ratio (OR); 2· 05, 95% Confidence Interval (CI)= 1· 08–
3· 89] and acute chest syndrome (ACS)[P= 0· 016, OR; 2· 56, CI= 1· 19, 5· 47], after adjusting
for age and gender in children with SCD. These findings suggest that haem and factors that …
Summary
We tested the hypothesis that extracellular haem is linked to the incidence of acute complications of sickle cell disease (SCD). Using multivariable regression analysis, higher plasma free haem, but not total plasma haem, was associated with increased odds of vaso‐occlusive crisis (VOC) [P = 0·028, odds ratio (OR); 2·05, 95% Confidence Interval (CI) = 1·08–3·89] and acute chest syndrome (ACS) [P = 0·016, OR; 2·56, CI = 1·19, 5·47], after adjusting for age and gender in children with SCD. These findings suggest that haem and factors that influence its concentration in plasma may be informative of the risk of VOC and ACS in SCD patients.
Wiley Online Library