[HTML][HTML] Neu differentiation factor/neuregulin isoforms activate distinct receptor combinations
R Pinkas-Kramarski, M Shelly, S Glathe… - Journal of Biological …, 1996 - ASBMB
The multiple isoforms of Neu differentiation factor (NDF/neuregulin) induce a pleiotropic
cellular response that is isoform-specific and cell type-dependent. The molecular basis of
this heterogeneity was addressed by comparing the two major groups of isoforms, α and β.
Both groups bind to the catalytically impaired receptor tyrosine kinase ErbB-3, whose
mitogenic stimulation by NDF requires transactivation by other ErbB proteins, either ErbB-1
or ErbB-2. By expressing each pair of receptors in interleukin 3-dependent myeloid cells, we …
cellular response that is isoform-specific and cell type-dependent. The molecular basis of
this heterogeneity was addressed by comparing the two major groups of isoforms, α and β.
Both groups bind to the catalytically impaired receptor tyrosine kinase ErbB-3, whose
mitogenic stimulation by NDF requires transactivation by other ErbB proteins, either ErbB-1
or ErbB-2. By expressing each pair of receptors in interleukin 3-dependent myeloid cells, we …
