Cyclin D3 expression in melanoma cells is regulated by adhesion-dependent phosphatidylinositol 3-kinase signaling and contributes to G1-S progression
LS Spofford, EV Abel, K Boisvert-Adamo… - Journal of biological …, 2006 - ASBMB
D-type cyclins regulate G 1 cell cycle progression by enhancing the activities of cyclin-
dependent kinases (CDKs), and their expression is frequently altered in malignant cells. We
and others have previously shown that cyclin D1 is up-regulated in melanoma cells through
adhesion-independent MEK-ERK1/2 signaling initiated by mutant B-RAF. Here, we describe
the regulation and role of cyclin D3 in human melanoma cells. Cyclin D3 expression was
enhanced in a cell panel of human melanoma cell lines compared with melanocytes and …
dependent kinases (CDKs), and their expression is frequently altered in malignant cells. We
and others have previously shown that cyclin D1 is up-regulated in melanoma cells through
adhesion-independent MEK-ERK1/2 signaling initiated by mutant B-RAF. Here, we describe
the regulation and role of cyclin D3 in human melanoma cells. Cyclin D3 expression was
enhanced in a cell panel of human melanoma cell lines compared with melanocytes and …
