Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate
OC Andronesi, O Rapalino, E Gerstner… - The Journal of …, 2013 - Am Soc Clin Investig
OC Andronesi, O Rapalino, E Gerstner, A Chi, TT Batchelor, DP Cahill, AG Sorensen…
The Journal of clinical investigation, 2013•Am Soc Clin InvestigThe investigation of metabolic pathways disturbed in isocitrate dehydrogenase (IDH) mutant
tumors revealed that the hallmark metabolic alteration is the production of D-2-
hydroxyglutarate (D-2HG). The biological impact of D-2HG strongly suggests that high levels
of this metabolite may play a central role in propagating downstream the effects of mutant
IDH, leading to malignant transformation of cells. Hence, D-2HG may be an ideal biomarker
for both diagnosing and monitoring treatment response targeting IDH mutations. Magnetic …
tumors revealed that the hallmark metabolic alteration is the production of D-2-
hydroxyglutarate (D-2HG). The biological impact of D-2HG strongly suggests that high levels
of this metabolite may play a central role in propagating downstream the effects of mutant
IDH, leading to malignant transformation of cells. Hence, D-2HG may be an ideal biomarker
for both diagnosing and monitoring treatment response targeting IDH mutations. Magnetic …
The investigation of metabolic pathways disturbed in isocitrate dehydrogenase (IDH) mutant tumors revealed that the hallmark metabolic alteration is the production of D-2-hydroxyglutarate (D-2HG). The biological impact of D-2HG strongly suggests that high levels of this metabolite may play a central role in propagating downstream the effects of mutant IDH, leading to malignant transformation of cells. Hence, D-2HG may be an ideal biomarker for both diagnosing and monitoring treatment response targeting IDH mutations. Magnetic resonance spectroscopy (MRS) is well suited to the task of noninvasive D-2HG detection, and there has been much interest in developing such methods. Here, we review recent efforts to translate methodology using MRS to reliably measure in vivo D-2HG into clinical research.
The Journal of Clinical Investigation